Lion’s mane mushrooms have been used for centuries in Chinese medicine. Lab and animal studies suggest this traditional medicine may help with many conditions. But there’s limited research in humans, and no product made from the mushrooms has been approved for the treatment of any condition.

The preliminary evidence suggests lion’s mane mushrooms can help in these ways. 

Fighting inflammation and free radicals 

Many health conditions, including heart disease, arthritis, and cancer, involve chronic inflammation and the effects of unstable molecules in our bodies called free radicals. Lion’s mane mushrooms contain potentially potent antioxidants, which are substances that limit the damage of free radicals. They also contain anti-inflammatory substances that show promise in animal studies. 

Fighting dementia and other brain diseases

Some studies in animals and small, preliminary studies in people suggest lion’s mane mushrooms might have a role in the prevention or treatment of cognitive decline, including Alzheimer’s disease. 

For example, in one study of 30 older adults with mild cognitive impairment, those who took tablets containing Hericium erinaceus powder for 4 months showed a temporary improvement on cognitive tests. The mushrooms have also been shown to slow Alzheimer’s symptoms and brain changes linked to the disease in mice. 

In another small human study, younger adults who took capsules of lion’s mane mushroom powder showed improved mental performance speed.

Lab studies show the mushrooms are a good source of hericenones and erinacines, two chemicals that accelerate the growth of brain cells.

Reducing anxiety and depression

Lion’s mane extracts could help treat some mental health conditions. To test this possibility, a study was carried out on Japanese women with many health conditions, including menopausal symptoms and poor sleep. Some were given cookies made with lion’s mane extracts while others were given placebo cookies for 4 weeks. 

The women who got the lion’s mane cookies reported lower levels of depressive symptoms and stress compared to the placebo group. 

Hericenones and erinacines, two kinds of chemicals in lion’s mane mushrooms, may be responsible for any antidepressant effect, researchers believe. These chemicals affect the release of nerve growth factor (NGF), a substance that regulates the growth and survival of brain cells. Conventional antidepressant drugs may work by changing NGF levels.

But lion’s mane mushroom treatments have not been tested head to head with such antidepressant drugs. 

Nerve regeneration

Lion’s mane mushrooms contain chemicals that  might promote the growth, survival, and function of both new and mature nerve cells in the brain and elsewhere. Animal studies suggest that these compounds, unlike some experimental treatments, are able to get from the bloodstream into the brain, crossing the so-called blood-brain barrier. 

For those reasons, there’s growing interest in trying the mushrooms in a long list of conditions, including:

• Stroke
• Parkinson’s disease
• Huntington’s disease
•  Multiple sclerosis
• Creutzfeldt-Jakob disease
•  Nerve injuries 

Managing diabetes

Lion’s mane mushrooms have been shown to lower blood sugar and raise insulin levels in lab rats with diabetes. Researchers think antioxidants in the mushrooms may explain these possible effects.

Research in animals also suggests the mushrooms might help with diabetic nerve pain.

Fighting stomach ulcers

Mushrooms, including lion’s mane mushrooms, are often used as stomach remedies in traditional medicine. In one rat study, extracts from lion’s mane mushrooms protected the animals from ulcers, partly by thickening mucus in the stomach lining. The researchers found that rats getting the highest doses of the extracts got the most protection.

Lab and animal studies also suggest the mushrooms can slow the growth of Helicobacter pylori (H. pylori), a type of bacteria linked with many stomach ulcers.

References : Medic